Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses
Abstract Most cancer patients diagnosed with late-stage head and neck squamous cell carcinoma are treated with chemoradiotherapy, which can lead to toxicity.One potential alternative is tumor-limited conversion of a prodrug into its cytotoxic form.We reason this could be achieved by transient and tumor-specific expression of purine nucleoside phosp